睾丸中线癌中的核蛋白在一名婴儿中表现为心包肿块，并通过氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描进行分期。

Nuclear Protein in Testis Midline Carcinoma Presenting in an Infant as a Pericardial Mass with Staging by F-Fluorodeoxyglucose-positron Emission Tomography/Computed Tomography.

作者信息

Perkins Crystal, Pucar Darko, McDonough Colleen H, Williams Hadyn T

机构信息

Medical Student, Augusta University/University of Georgia Medical Partnership, Augusta, Georgia, USA.

Department of Radiology and Imaging, Nuclear Medicine Section, Medical College of Georgia, Augusta University, Georgia, USA.

出版信息

World J Nucl Med. 2017 Jul-Sep;16(3):247-250. doi: 10.4103/1450-1147.207284.

DOI:10.4103/1450-1147.207284

PMID:28670187

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5460312/

Abstract

Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare, aggressive, lethal, epithelioid, poorly differentiated cancer first described in Japan in 1991, unique in that is defined genetically rather than by histological tissue of origin. It usually arises in the body midline and presents as a mass with metastasis. An infant presenting with pneumonia was found to have a pericardial mass, NMC resected, and subsequent staging positron emission tomography (PET) showing residual mediastinal tumor and midline abdominal metastases. Fewer than 100 cases of NMC have been reported in the literature, and PET appears to be the imaging modality of choice in complete staging and evaluation of treatment response.

摘要

睾丸核蛋白（NUT）中线癌（NMC）是一种罕见、侵袭性强、致命的上皮样低分化癌，于1991年在日本首次被描述，其独特之处在于它是由基因定义而非组织学起源组织来定义。它通常发生于身体中线部位，表现为伴有转移的肿块。一名因肺炎就诊的婴儿被发现有心包肿块，切除了NMC，随后的分期正电子发射断层扫描（PET）显示纵隔肿瘤残留及中线腹部转移。文献报道的NMC病例少于100例，PET似乎是进行完整分期和评估治疗反应的首选成像方式。