Gupta Akshita, Bopanna Sawan, Kedia Saurabh, Yadav Dawesh Prakash, Goyal Sandeep, Jain Saransh, Makharia Govind, Ahuja Vineet
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Intest Res. 2017 Jul;15(3):388-394. doi: 10.5217/ir.2017.15.3.388. Epub 2017 Jun 12.
BACKGROUND/AIMS: Familial occurrence of inflammatory bowel disease (IBD) is well documented. Reports from Western countries have shown a higher familial occurrence of ulcerative colitis (UC) in first- and second-degree relatives than that in the Asian UC population. No data are currently available from the Indian subcontinent in this regard. We present our data on the familial aggregation of UC.
Records of patients with UC followed at the Inflammatory Bowel Disease Clinic at the All India Institute of Medical Sciences, New Delhi from August 2004 to January 2016 were reviewed. Details regarding the prevalence of family history and characteristics of these patients were recorded. Affected family members were contacted and disease characteristics were noted for assessment of familial aggregation.
Of the 2,058 UC patients included in the analysis, a positive family history of IBD was confirmed in 31 patients (1.5%), 24 (77.4%) of whom had only first-degree relatives affected. All the affected relatives had UC and none had Crohn's disease. Among first-degree relatives, siblings were found to have the highest prevalence of IBD (53.3%), followed by parents (26.7%).
The probability of occurrence of IBD in family members of affected North Indian UC patients is lower than that reported in Western populations.
背景/目的：炎症性肠病（IBD）的家族聚集现象已有充分记录。西方国家的报告显示，溃疡性结肠炎（UC）在一级和二级亲属中的家族聚集发生率高于亚洲UC人群。目前尚无来自印度次大陆这方面的数据。我们展示了关于UC家族聚集性的数据。
回顾了2004年8月至2016年1月在新德里全印度医学科学研究所炎症性肠病诊所随访的UC患者记录。记录了这些患者家族史的患病率及特征细节。联系了受影响的家庭成员并记录疾病特征以评估家族聚集性。
纳入分析的2058例UC患者中，31例（1.5%）确诊有IBD家族史阳性，其中24例（77.4%）仅有一级亲属受影响。所有受影响的亲属均患有UC，无克罗恩病患者。在一级亲属中，兄弟姐妹的IBD患病率最高（53.3%），其次是父母（26.7%）。
受影响的北印度UC患者家庭成员发生IBD的概率低于西方人群报告的概率。
