Park Jong Beom, Yang Suk-Kyun, Byeon Jeong-Sik, Park Eui-Ryun, Moon Gyoo, Myung Seung Jae, Park Won Kap, Yoon Seo Gue, Kim Hyun Shig, Lee Jong Gyun, Kim Jin Ho, Il Min Young, Kim Kwang Yeon
Departments of Internal Medicine and Surgery, Song Do Colorectal Hospital, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Korea.
Inflamm Bowel Dis. 2006 Dec;12(12):1146-51. doi: 10.1097/01.mib.0000235094.01608.59.
Little information is available about the familial aggregation of inflammatory bowel disease (IBD) in Asian populations. We therefore determined the risk of familial aggregation of IBD among first-degree relatives of patients with ulcerative colitis (UC) or Crohn's disease (CD) in an ethnically distinct Korean population.
Familial aggregation of IBD was evaluated in terms of family history, prevalence, lifetime risk, and population relative risk in first-degree relatives of 1440 unrelated patients with UC (n = 1043) or CD (n = 397).
A positive first-degree family history of IBD was observed in 27 probands (1.88%): 21 of 1043 (2.01%) with UC and 6 of 397 (1.51%) with CD. The crude prevalence of IBD in first-degree relatives of probands with IBD was 0.31%. The lifetime risk of IBD was 0.54% in all first-degree relatives of IBD probands, 0.52% in UC probands, and 0.67% in CD probands, with overall lifetime relative risks of 0.12% in parents, 0.79% in siblings, and 1.43% in offspring. The age- and sex-adjusted population relative risk of IBD was 13.8 in first-degree relatives of probands with IBD.
Although a positive family history, prevalence, and lifetime risk of IBD among first-degree relatives of Korean IBD patients are much lower than among relatives of Western patients, the population relative risk in first-degree relatives is about equal in Koreans and Westerners. This finding indicates that a positive family history is an important risk factor for IBD in Koreans and in Westerners.
关于亚洲人群炎症性肠病（IBD）的家族聚集性，目前可用信息较少。因此，我们在一个种族独特的韩国人群中，确定了溃疡性结肠炎（UC）或克罗恩病（CD）患者的一级亲属患IBD的家族聚集风险。
通过家族史、患病率、终生风险以及1440例无亲缘关系的UC患者（n = 1043）或CD患者（n = 397）的一级亲属的人群相对风险，评估IBD的家族聚集性。
在27名先证者（1.88%）中观察到IBD的一级家族史阳性：1043例UC患者中有21例（2.01%），397例CD患者中有6例（1.51%）。IBD先证者的一级亲属中IBD的粗患病率为0.31%。IBD先证者的所有一级亲属的终生风险为0.54%，UC先证者为0.52%，CD先证者为0.67%，父母的总体终生相对风险为0.12%，兄弟姐妹为0.79%，后代为1.43%。IBD先证者的一级亲属中，经年龄和性别调整后的IBD人群相对风险为13.8。
尽管韩国IBD患者的一级亲属中IBD的阳性家族史、患病率和终生风险远低于西方患者的亲属，但韩国人和西方人一级亲属中的人群相对风险大致相当。这一发现表明，阳性家族史是韩国人和西方人患IBD的重要风险因素。
