Mandavdhare Harshal Surendra, Sharma Vishal, Prasad Kaushal K, Kumar Amit, Rathi Manish, Rana Surinder S
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Intest Res. 2017 Jul;15(3):419-421. doi: 10.5217/ir.2017.15.3.419. Epub 2017 Jun 12.
Recent studies have identified sprue-like illness associated with the use of the antihypertensive agent olmesartan medoxomil. However, whether this condition is specific to the use of olmesartan or is associated with the use of drugs belonging to the class of "sartans" remains to be clarified. A 45-year-old woman with chronic kidney disease along with hypothyroidism and hypertension presented with chronic diarrhea and significant weight loss. Endoscopy of the upper gastrointestinal tract showed scalloping and grooving of the duodenum, and histopathological examination showed subtotal villous atrophy. She was on telmisartan for hypertension, which was discontinued. Subsequently, diarrhea ameliorated dramatically, and she regained weight. To our knowledge, this is the first study to report telmisartan-associated sprue-like enteropathy. Further, we have reviewed the cases of patients with sprue-like enteropathy caused by valsartan, irbesartan, and eprosartan.
近期研究已确认使用抗高血压药物奥美沙坦酯会引发类口炎性腹泻疾病。然而，这种情况是奥美沙坦所特有的，还是与“沙坦类”药物的使用有关，仍有待阐明。一名45岁患有慢性肾脏病、甲状腺功能减退和高血压的女性出现慢性腹泻和显著体重减轻。上消化道内镜检查显示十二指肠有扇贝样改变和沟纹，组织病理学检查显示绒毛部分萎缩。她正在服用替米沙坦治疗高血压，该药已停用。随后，腹泻显著改善，体重也恢复了。据我们所知，这是第一项报告替米沙坦相关类口炎性肠病的研究。此外，我们还回顾了由缬沙坦、厄贝沙坦和依普罗沙坦引起的类口炎性肠病患者病例。
