施陶丁格连接反应在获取中性环状二核苷酸类似物前体方面的一种新应用——一种发散性方法。
A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors a divergent method.
作者信息
Fletcher M H, Burns-Lynch C E, Knouse K W, Abraham L T, DeBrosse C W, Wuest W M
机构信息
Department of Chemistry, Temple University, Philadelphia, PA 19122, USA.
Department of Chemistry, Emory University, Atlanta, GA 30322, USA. Email:
出版信息
RSC Adv. 2017 Jun 7;7(47):29835-29838. doi: 10.1039/c7ra06045a.
Abstract
Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea linkages.
摘要
我们致力于开发一种可扩展且具有多样性的环状二核苷酸类似物前体的合成方法，这带来了以下成果：（1）一种正交保护的二氨基碳水化合物，以及（2）施陶丁格连接反应的新应用，以提供具有氨基甲酸酯或脲键的中等大小大环化合物。
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