Bostofte E, Serup J, Rebbe H
Int J Fertil. 1985;30(3):31-7.
The clinical fertility of 1,077 men whose semen had been analyzed between 1950 and 1952, in terms of types of abnormal spermatozoa morphology according to the Hammen system with 14 types, was studied 20 years later by means of a questionnaire (785 replies i.e., 72.9%). There was a significant difference (P less than or equal to 0.01) between couples who obtained living children and the couples who did not, expressed as the mean percentages of spermatozoa with narrow heads, round heads, amorphous heads, irregular heads, abortive forms, double forms, staining abnormalities and vacuoles. The same tendency was found for piriform heads, small heads, belted heads and various rare heads. Giant head showed no difference, and pinhead was not represented. Piriform heads and narrow heads increased significantly more than the other types (P less than or equal to 0.01) with increasing total number of abnormal spermatozoa. There was no relation between any abnormal type and abortions and otherwise abnormal pregnancies. Detection of types of abnormal spermatozoa morphology does not seem to improve semen analysis in terms of predicting chance of pregnancy, and we prefer to use the percentage of morphologically normal spermatozoa, the inverse expression of abnormal spermatozoal morphology as a total, for routine semen analysis.
1950年至1952年间对精液进行分析的1077名男性的临床生育能力，依据哈门系统的14种异常精子形态类型进行了研究。20年后通过问卷调查（共收到785份回复，即回复率为72.9%）。在已生育存活子女的夫妇与未生育的夫妇之间，以头部狭窄、头部圆形、无定形头部、不规则头部、发育不全形态、双形态、染色异常和空泡的精子平均百分比表示，存在显著差异（P≤0.01）。对于梨形头部、小头部、带环头部和各种罕见头部，也发现了相同的趋势。巨头畸形无差异，且未出现针头状头部。随着异常精子总数的增加，梨形头部和狭窄头部的增加幅度明显大于其他类型（P≤0.01）。任何异常类型与流产及其他异常妊娠之间均无关联。就预测妊娠几率而言，检测异常精子形态类型似乎并不能改善精液分析，并且我们更倾向于使用形态正常精子的百分比，即异常精子形态总数的反表示法，用于常规精液分析。
