Keller H U, Zimmermann A
Invasion Metastasis. 1986;6(1):33-43.
Two morphologically distinct types of polarization and locomotion are found in Walker carcinosarcoma cells. Spontaneously polarized cells are characterized by formation of ruffles and spikes, cells polarized in the presence of microtubule-disassembling drugs by blebbing at the leading edge. Polarization and locomotion are closely correlated. Both can be stimulated by the microtubule-disassembling agents colchicine, nocodazole and vinblastine and suppressed by taxol or cytochalasin B. The results suggest that both microfilaments and microtubules may be involved in regulating polarization and chemokinesis, and that shape changes elicited by microtubule-disassembling agents depend on microfilaments.
在沃克癌肉瘤细胞中发现了两种形态上不同的极化和运动类型。自发极化的细胞以形成褶皱和刺突为特征，在微管拆卸药物存在的情况下极化的细胞在前缘形成泡状突起。极化和运动密切相关。两者都可被微管拆卸剂秋水仙碱、诺考达唑和长春碱刺激，并被紫杉醇或细胞松弛素B抑制。结果表明，微丝和微管可能都参与调节极化和化学动力学，并且微管拆卸剂引起的形状变化取决于微丝。
