尼日利亚拉各斯一家二级医疗机构中接受管理的药物敏感型结核病患者中与结核病/艾滋病毒合并感染相关的因素
FACTORS ASSOCIATED WITH TB/HIV CO-INFECTION AMONG DRUG SENSITIVE TUBERCULOSIS PATIENTS MANAGED IN A SECONDARY HEALTH FACILITY IN LAGOS, NIGERIA.
作者信息
Adejumo Olusola A, Daniel Olusoji J, Otesanya Andrew F, Adegbola Adebukola A, Femi-Adebayo Temitope, Bowale Abimbola, Adesola Sunday, Kuku Olugbenga O, Otemuyiwa Kehinde O, Oladega Shafaatu N, Johnson Eze O, Falana Ayodeji A, Dawodu Olusola, Owuna Henry, Osoba Ganiyat, Dacosta Adetokunbo
机构信息
Department of Community Health and Primary Health Care, Lagos State University Teaching Hospital, Ikeja Lagos, Nigeria.
Department of Community Medicine and Primary Care, Olabisi Onabanjo University Teaching Hospital Sagamu Ogun State.
出版信息
Afr J Infect Dis. 2017 Jun 8;11(2):75-82. doi: 10.21010/ajid.v11i2.10. eCollection 2017.
BACKGROUND
This study assessed factors associated with TB/HIV co-infection among TB patients managed in a secondary health facility in Lagos Nigeria.
MATERIALS AND METHODS
A retrospective review of treatment cards of patients seen at a secondary referral hospital between January 1 2014 and December 31 2014 was conducted. Treatment outcomes and factors associated with TB/HIV co-infection were assessed.
RESULTS
Of the 334 records of patients reviewed, the proportion of patients with TB/HIV co-infection was 21.6%. The odds of having TB/HIV co-infection was 2.7 times higher among patients above 40 years than patients less than 25 years (AOR 2.7 95% CI 1.1 - 6.5, p =0.030). In addition, the odds of having TB/HIV co-infection was 3.3 higher among extra-pulmonary TB cases (AOR 3.3; 95% CI 1.2 - 9.5; p = 0.026) and 2.1 times higher among retreated patients (AOR 2.1; 95% CI 1.1 - 3.9; p = 0.017) than pulmonary TB and new patients respectively. The chance of having TB/HIV co-infection was 2.7-fold more in patients with poor treatment outcomes than patients with treatment success (AOR 2.7; 95%CI 1.3 - 5.4; p =0.006).
CONCLUSION
TB/HIV co-infection rate was high in the study area. There is need to put measures in place to improve treatment outcomes of TB/HIV co-infected patients.
背景
本研究评估了在尼日利亚拉各斯一家二级医疗机构接受治疗的结核病患者中与结核病/艾滋病病毒合并感染相关的因素。
材料与方法
对2014年1月1日至2014年12月31日在一家二级转诊医院就诊的患者的治疗卡片进行回顾性分析。评估治疗结果以及与结核病/艾滋病病毒合并感染相关的因素。
结果
在审查的334份患者记录中，结核病/艾滋病病毒合并感染患者的比例为21.6%。40岁以上患者发生结核病/艾滋病病毒合并感染的几率比25岁以下患者高2.7倍（调整后比值比2.7，95%置信区间1.1 - 6.5，p = 0.030）。此外，肺外结核病例发生结核病/艾滋病病毒合并感染的几率比肺结核病例高3.3倍（调整后比值比3.3；95%置信区间1.2 - 9.5；p = 0.026），复治患者发生结核病/艾滋病病毒合并感染的几率比新患者高2.1倍（调整后比值比2.1；95%置信区间1.1 - 3.9；p = 0.017）。治疗效果不佳的患者发生结核病/艾滋病病毒合并感染的几率比治疗成功的患者高2.7倍（调整后比值比2.7；95%置信区间1.3 - 5.4；p = 0.006）。
结论
研究区域内结核病/艾滋病病毒合并感染率较高。需要采取措施改善结核病/艾滋病病毒合并感染患者的治疗效果。
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