Hancu Gabriel, Cârcu-Dobrin Melania, Budău Monica, Rusu Aura
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy, Tîrgu Mureş, Romania.
Biomed Chromatogr. 2018 Jan;32(1). doi: 10.1002/bmc.4040. Epub 2017 Jul 26.
Fluoxetine is a widely used antidepressant belonging to the selective serotonin reuptake inhibitor class; it is used in the treatment of major depression, obsessive compulsive, premenstrual dysphoric, panic and post-traumatic stress disorders. Fluoxetine is an optical active pharmaceutical substance, which is used as a racemate in therapy, but stereospecific interactions associated with the serotonin-reuptake carrier, for both the parent drug and its active metabolite, norfluoxetine, have been described in the literature. Therefore, the stereoselective analysis of fluoxetine and norfluoxetine is important in order to characterize the pharmacokinetic and pharmacodynamic profile of the analytes. Several chromatographic and electrophoretic methods have been published in the literature for the chiral discrimination of fluoxetine enantiomers from different matrices. The purpose of the current review is to provide a systematic survey of the analytical techniques used for the chiral determination of fluoxetine and norfluoxetine covering a period of ~25 years.
氟西汀是一种广泛使用的抗抑郁药，属于选择性5-羟色胺再摄取抑制剂类；它用于治疗重度抑郁症、强迫症、经前烦躁症、恐慌症和创伤后应激障碍。氟西汀是一种旋光性药物物质，在治疗中作为消旋体使用，但文献中已描述了母体药物及其活性代谢物去甲氟西汀与5-羟色胺再摄取载体相关的立体特异性相互作用。因此，氟西汀和去甲氟西汀的立体选择性分析对于表征分析物的药代动力学和药效学特征很重要。文献中已发表了几种色谱和电泳方法用于从不同基质中对手性氟西汀对映体进行鉴别。本综述的目的是对用于氟西汀和去甲氟西汀手性测定的分析技术进行系统综述，涵盖约25年的时间。
