Hancu Gabriel, Budău Monica, Muntean Daniela Lucia, Gagyi Laszlo, Rusu Aura
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu Mureș, Romania.
Department of Analytical Chemistry and Drug Analysis, Faculty of Pharmacy, University of Medicine and Pharmacy of Tîrgu Mureș, Romania.
Biomed Chromatogr. 2018 Nov;32(11):e4335. doi: 10.1002/bmc.4335. Epub 2018 Aug 14.
Chirality is a key subject in modern drug research as well as in the pharmaceutical industry and drug development. Almost all second-generation modern antidepressants are chiral substances; however in therapy some are used as racemic mixtures while others are used as pure enantiomers. The development of enantioseparation methods of chiral antidepressants and their metabolites is one of the keys in understanding their enantioselective drug action. For this purpose, efficient and reliable analytical methods are needed, and capillary electrophoresis has proved to be an interesting and advantageous alternative to the more frequently used chromatographic techniques. In this review electrodriven methods available for the chiral discrimination of selective serotonin reuptake inhibitors (fluoxetine, citalopram, sertraline) and selective serotonin and norepinephrine reuptake inhibitors (venlafaxine, duloxetine) are presented and discussed.
手性是现代药物研究以及制药行业和药物开发中的一个关键课题。几乎所有第二代现代抗抑郁药都是手性物质；然而在治疗中，有些被用作外消旋混合物，而有些则被用作纯对映体。手性抗抑郁药及其代谢物的对映体分离方法的开发是理解其对映体选择性药物作用的关键之一。为此，需要高效可靠的分析方法，而毛细管电泳已被证明是比更常用的色谱技术更有趣且更具优势的替代方法。在这篇综述中，介绍并讨论了可用于选择性5-羟色胺再摄取抑制剂（氟西汀、西酞普兰、舍曲林）和选择性5-羟色胺及去甲肾上腺素再摄取抑制剂（文拉法辛、度洛西汀）手性鉴别的电动方法。
