Li Dan, Wu Chuancheng, Cai Yuanhua, Liu Baoying
1 Fujian Health College, Fuzhou, China.
2 School of Public Health, Fujian Medical University, Fuzhou, China.
Tumour Biol. 2017 Jul;39(7):1010428317717107. doi: 10.1177/1010428317717107.
Xianyou county of Fujian province, located on the southeast coastal of China, has higher gastric cancer mortality. Chronic inflammation plays an important role in the occurrence of gastric cancer, in which the nuclear factor-κB signaling pathway of the inflammatory reaction begins and plays an important role in the amplification process. Studies have found that a single-nucleotide polymorphism of nuclear factor-κB signaling pathway molecules encoding genes is associated with gastric cancer, but the combined effect of the nuclear factor-κB signaling pathway gene has not been explained nor has been cardia and non-cardia gastric cancer risk factors and genetic susceptibility loci. New gastric cancer cases of the Fujian Xianyou Hospital were the research object. They were divided into cardia and non-cardia cancer in order to study a single-nucleotide polymorphism of the nuclear factor-κB signaling pathway important node molecules P50 and I kappa B encoding genes NFKB1 and NFKBIA by desorption ionization time of flight mass spectrometry analysis and by matrix-assisted laser mass spectrometry. The results showed that NFKB1 and NFKBIA single-nucleotide polymorphisms and gastric cancer are related and that the combined effects of polymorphisms in two genes and the NFKBIA gene monomer increased the risk of gastric cancer, and it was found that in different types of gastric cancer (the cardia and non-cardia cancer), susceptible polymorphism sites and combined effects are different.
福建省仙游县位于中国东南沿海，胃癌死亡率较高。慢性炎症在胃癌发生中起重要作用，其中炎症反应的核因子-κB信号通路起始并在放大过程中起重要作用。研究发现，核因子-κB信号通路分子编码基因的单核苷酸多态性与胃癌有关，但核因子-κB信号通路基因的联合作用尚未得到阐释，贲门癌和非贲门癌的危险因素及遗传易感位点也未明确。以福建省仙游县医院的新发胃癌病例为研究对象，将其分为贲门癌和非贲门癌，采用解吸电离飞行时间质谱分析法和基质辅助激光质谱法，研究核因子-κB信号通路重要节点分子P50和IκB编码基因NFKB1和NFKBIA的单核苷酸多态性。结果显示，NFKB1和NFKBIA单核苷酸多态性与胃癌有关，两基因多态性的联合作用及NFKBIA基因单体均增加了胃癌风险，且发现在不同类型胃癌（贲门癌和非贲门癌）中，易感多态性位点及联合作用存在差异。
