Stefanini S, Farrace M G, Argento M P
J Embryol Exp Morphol. 1985 Aug;88:151-63.
Organules containing cytochemically detectable amounts of catalase and D-aminoacid oxidase activities are observed between the 14th and 21st day of development in the parenchymal cells of the foetal rat liver and in the liver of newborn rats. As early as 14 to 15 days, a limited number of small microperoxisomes, scattered in the cytoplasm of very few hepatocytes, can be found. These are roundish shaped, have a granulous matrix and contain very low, hardly detectable levels of the above mentioned enzymes. In later development both the size and the enzymatic content of the organules gradually increase, approaching adult levels at the end of foetal development. Starting from the 18th to 19th day of intrauterine life nucleoids can be seen in many peroxisomes. The morphological and biochemical maturation from microperoxisomes to peroxisomes is accompanied by a gradual increase in the number of stainable organules, both per individual cell and per tissue area.
在胎鼠肝脏实质细胞和新生大鼠肝脏中，于发育的第14天至21天观察到含有细胞化学可检测量的过氧化氢酶和D -氨基酸氧化酶活性的细胞器。早在14至15天时，可发现有限数量的小微型过氧化物酶体，散布在极少数肝细胞的细胞质中。它们呈圆形，具有颗粒状基质，且上述酶的含量极低，几乎难以检测到。在随后的发育过程中，细胞器的大小和酶含量逐渐增加，在胎儿发育末期接近成年水平。从子宫内生活的第18天至19天开始，在许多过氧化物酶体中可见核仁。从微型过氧化物酶体到过氧化物酶体的形态和生化成熟伴随着每个细胞和每个组织区域中可染色细胞器数量的逐渐增加。
