Hughes J L, Bourne A J, Poulos A
Department of Histopathology, Adelaide Children's Hospital, South Australia.
Virchows Arch A Pathol Anat Histopathol. 1993;423(6):453-7. doi: 10.1007/BF01606535.
The size and number of hepatic peroxisomes was investigated in 16 control paediatric liver biopsies from patients ranging in age from 3 months to 18 years one fetal liver specimen and one paediatric autopsy liver. The area, diameter, volume density (Vv), numerical density (Nv) and surface density (Sv) of the peroxisomes was recorded using randomly selected electron micrographs. The mean diameter of peroxisomes in control paediatric liver was 0.56 microns, the mean Vv was 1.67%, the mean Nv was 0.125 per micron+3 and the mean Sv was 0.161 per micron. No correlation was found between the size and number of hepatic peroxisomes and the age or sex of the patient. Peroxisomes in the fetal liver were smaller than those in biopsy tissue and had a mean diameter of 0.42 micron. Peroxisomes were identified in autopsy tissue and were enlarged with a mean diameter of 0.75 micron, most probably due to post-mortem swelling. A range of morphometric values in paediatric liver has now been established.
对16例年龄在3个月至18岁的对照儿童肝脏活检标本、1例胎儿肝脏标本和1例儿童尸检肝脏进行了肝过氧化物酶体大小和数量的研究。使用随机选择的电子显微镜照片记录过氧化物酶体的面积、直径、体积密度（Vv）、数量密度（Nv）和表面密度（Sv）。对照儿童肝脏中过氧化物酶体的平均直径为0.56微米，平均Vv为1.67%，平均Nv为每微米0.125+3，平均Sv为每微米0.161。未发现肝过氧化物酶体的大小和数量与患者年龄或性别之间存在相关性。胎儿肝脏中的过氧化物酶体比活检组织中的小，平均直径为0.42微米。在尸检组织中发现了过氧化物酶体，其增大，平均直径为0.75微米，很可能是由于死后肿胀。现已确定了儿童肝脏的一系列形态测量值。
