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甲氧氯普胺和ICS 205 - 930对豚鼠5 - 羟色胺受体的拮抗作用导致电场刺激引起的胃肌条收缩增强以及体内胃排空加快。

5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205-930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in-vivo.

作者信息

Buchheit K H, Costall B, Engel G, Gunning S J, Naylor R J, Richardson B P

出版信息

J Pharm Pharmacol. 1985 Sep;37(9):664-7. doi: 10.1111/j.2042-7158.1985.tb05109.x.

DOI:10.1111/j.2042-7158.1985.tb05109.x
PMID:2867192
Abstract

Contractions induced by electrical field stimulation of isolated circular muscle strips, taken from the guinea-pig stomach, were enhanced by metoclopramide, ICS 205-930 and MDL 72222 at concentrations similar to those shown to antagonize at neuronal 5-hydroxytryptamine receptor sites in a variety of preparations. Metoclopramide, MDL 72222 and ICS 205-930 also facilitated gastric emptying in-vivo. The abilities of metoclopramide, MDL 72222 and ICS 205-930 to enhance stomach muscle contraction processes and to facilitate gastric emptying may be the consequence of 5-hydroxytryptamine receptor antagonism.

摘要

从豚鼠胃中取出的离体环形肌条经电场刺激引起的收缩，在与多种制剂中显示出对神经元5-羟色胺受体位点有拮抗作用的浓度相似时，被甲氧氯普胺、ICS 205-930和MDL 72222增强。甲氧氯普胺、MDL 72222和ICS 205-930在体内也促进胃排空。甲氧氯普胺、MDL 72222和ICS 205-930增强胃肌收缩过程和促进胃排空的能力可能是5-羟色胺受体拮抗作用的结果。

相似文献

1
5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205-930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in-vivo.甲氧氯普胺和ICS 205 - 930对豚鼠5 - 羟色胺受体的拮抗作用导致电场刺激引起的胃肌条收缩增强以及体内胃排空加快。
J Pharm Pharmacol. 1985 Sep;37(9):664-7. doi: 10.1111/j.2042-7158.1985.tb05109.x.
2
Modification of electrical field stimulation-induced contractions in the guinea-pig ileum by metoclopramide and ICS 205-930 depends on the integrity of the mucosa.
J Pharm Pharmacol. 1986 Nov;38(11):811-4. doi: 10.1111/j.2042-7158.1986.tb04500.x.
3
Stimulant effects of 5-hydroxytryptamine on guinea pig stomach preparations in vitro.5-羟色胺对豚鼠胃离体标本的兴奋作用。
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4
Evidence that 5-hydroxytryptamine may exert both facilitatory and inhibitory control of electrical field stimulation-evoked contractions in longitudinal muscle taken from the body of guinea-pig stomach.有证据表明，5-羟色胺可能对取自豚鼠胃体的纵行肌中电场刺激诱发的收缩产生促进和抑制性控制。
J Pharm Pharmacol. 1986 Mar;38(3):182-7. doi: 10.1111/j.2042-7158.1986.tb04541.x.
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5-Hydroxytryptamine can antagonize the ability of metoclopramide and SCH 23390 to enhance electrical field stimulation-evoked contractions of guinea-pig isolated stomach muscle.
J Pharm Pharmacol. 1985 Jan;37(1):78-80. doi: 10.1111/j.2042-7158.1985.tb04941.x.
6
Activation of a myenteric 5-hydroxytryptamine-like receptor by metoclopramide.甲氧氯普胺对肌间神经丛5-羟色胺样受体的激活作用。
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Neuronally mediated contraction responses of guinea-pig stomach smooth muscle preparations: modification by benzamide derivatives does not reflect a dopamine antagonist action.豚鼠胃平滑肌制剂的神经介导收缩反应：苯甲酰胺衍生物的修饰并不反映多巴胺拮抗剂作用。
Eur J Pharmacol. 1984 Jun 15;102(1):79-89. doi: 10.1016/0014-2999(84)90340-6.
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Ondansetron facilitates neuromuscular transmission in the guinea-pig ileum.
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SCH 23390 can enhance field stimulation-induced contractions of longitudinal smooth muscle from guinea-pig stomach.
J Pharm Pharmacol. 1984 May;36(5):356. doi: 10.1111/j.2042-7158.1984.tb04397.x.

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