ICS 205-930（一种特异性5-羟色胺3受体拮抗剂）对正常受试者固体餐胃排空的影响。
Effect of ICS 205-930 (a specific 5-HT3 receptor antagonist) on gastric emptying of a solid meal in normal subjects.
作者信息
Akkermans L M, Vos A, Hoekstra A, Roelofs J M, Horowitz M
机构信息
Department of Surgery, University Hospital Utrecht, The Netherlands.
出版信息
Gut. 1988 Sep;29(9):1249-52. doi: 10.1136/gut.29.9.1249.
Abstract
The effects on gastric emptying of a solid meal of the specific 5-HT3-receptor antagonist ICS 205-930, 10 mg and 20 mg intravenously were assessed with a scintigraphic technique in 12 normals. The 50% emptying time was less, the lag phase was shorter and the post lag emptying rate was faster after 20 mg ICS 205-930 (p less than 0.02). After 10 mg ICS 205-930 the lag phase was significantly shorter compared with placebo (p less than 0.04). These results suggest that 5-HT3 receptors may be involved in the regulation of gastric emptying in man.
摘要
采用闪烁扫描技术，在12名正常人中评估了静脉注射10毫克和20毫克特异性5-羟色胺3（5-HT3）受体拮抗剂ICS 205-930对固体食物胃排空的影响。注射20毫克ICS 205-930后，50%排空时间缩短，延迟期缩短，延迟后排空速率加快（p<0.02）。注射10毫克ICS 205-930后，与安慰剂相比，延迟期显著缩短（p<0.04）。这些结果表明，5-HT3受体可能参与人体胃排空的调节。
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