纳洛酮对左旋多巴诱发的小鼠震颤有选择性增强作用，但对阿托品抑制毒蕈碱诱发的小鼠震颤无此作用。
A selective potentiation by naloxone of L-dopa but not atropine suppression of oxotremorine-induced tremor in mice.
作者信息
Quock R M, Lucas T S
出版信息
J Pharm Pharmacol. 1985 Sep;37(9):673-4. doi: 10.1111/j.2042-7158.1985.tb05113.x.
Abstract
Oxotremorine-induced tremor activity in mice was suppressed by pretreatment with either L-dopa or atropine. Additional pretreatment with the opiate receptor blocker naloxone significantly potentiated the antitremor effect of L-dopa but not that of atropine. These findings indicate a selectivity of drug interaction between naloxone and L-dopa.
摘要
用左旋多巴或阿托品预处理可抑制氧化震颤素诱发的小鼠震颤活动。用阿片受体阻断剂纳洛酮进行额外预处理可显著增强左旋多巴的抗震颤作用，但对阿托品的抗震颤作用无此效果。这些发现表明纳洛酮与左旋多巴之间存在药物相互作用的选择性。
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