纳洛酮对左旋多巴抗氧代震颤素作用的增强效应。

Potentiation by naloxone of the anti-oxotremorine effect of L-DOPA.

作者信息

Quock R M, Lucas T S

出版信息

Eur J Pharmacol. 1983 Nov 25;95(3-4):193-8. doi: 10.1016/0014-2999(83)90634-9.

Abstract

Pretreatment with the catecholamine precursor L-DOPA but not the narcotic antagonist naloxone suppressed the tremorigenic effect of oxotremorine in mice. However, when animals were pretreated with both L-DOPA and several different doses of naloxone, there was a dose-related potentiation of the antitremor effect of L-DOPA. Naloxone also produced dose-dependent potentiation of the antitremor activity of lower doses of L-DOPA in the presence of the peripheral decarboxylase inhibitor carbidopa. These findings suggest a possible therapeutic application for naloxone in treatment of dopamine dysfunction disorders.

摘要

用儿茶酚胺前体左旋多巴预处理可抑制毒扁豆碱对小鼠的致震颤作用，而用麻醉拮抗剂纳洛酮预处理则无此作用。然而，当动物同时用左旋多巴和几种不同剂量的纳洛酮预处理时，左旋多巴的抗震颤作用出现剂量相关的增强。在存在外周脱羧酶抑制剂卡比多巴的情况下，纳洛酮也能使较低剂量左旋多巴的抗震颤活性产生剂量依赖性增强。这些发现提示纳洛酮在治疗多巴胺功能障碍性疾病方面可能具有治疗应用价值。