Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd. NW. #20, Washington, DC 20016, United States.
Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd. NW. #20, Washington, DC 20016, United States.
Arch Oral Biol. 2017 Oct;82:263-270. doi: 10.1016/j.archoralbio.2017.06.022. Epub 2017 Jun 16.
To determine changes in saliva sonic hedgehog (Shh) and in taste dysfunction before and after oral theophylline treatment.
Shh was measured in parotid saliva of both normal subjects and patients with taste dysfunction of multiple etiologies by use of a sensitive spectrophotometric ELISA assay. Taste dysfunction was defined clinically by both subjective inhibition of taste function (including acuity loss) and impaired gustometry.
Theophylline treatment increased patient saliva Shh and improved taste dysfunction both subjectively and by gustometry.
By use of these systematic clinical measurements theophylline can be demonstrated to increase saliva Shh and improve taste dysfunction. These results are consistent with saliva Shh acting as a taste bud growth factor which stimulates stem cells of taste buds to initiate development and perpetuation of taste bud receptors. Measurements of saliva Shh provide an important marker for the presence of taste dysfunction and in the improvement by theophylline treatment.
确定口服茶碱治疗前后唾液 sonic 刺猬因子（Shh）和味觉障碍的变化。
使用灵敏的分光光度酶联免疫吸附试验（ELISA）检测，在正常受试者和味觉障碍的多种病因患者的腮腺唾液中测量 Shh。味觉障碍通过主观味觉功能抑制（包括味觉丧失）和味觉测量受损来临床定义。
茶碱治疗增加了患者唾液中的 Shh，改善了味觉障碍的主观和味觉测量。
通过这些系统的临床测量，可以证明茶碱可以增加唾液 Shh 并改善味觉障碍。这些结果与唾液 Shh 作为味觉感受器生长因子一致，刺激味觉感受器的干细胞启动味觉感受器的发育和维持。唾液 Shh 的测量为味觉障碍的存在以及茶碱治疗的改善提供了一个重要的标志物。
