类鼻疽中的胃肠道受累情况。
Gastrointestinal tract involvement in melioidosis.
作者信息
Teparrukkul Prapit, Kongkasame Worrarat, Chitsaeng Songla, Wongsuwan Gumphol, Wuthiekanun Vanaporn, Peacock Sharon J, Limmathurotsakul Direk
机构信息
Medical Department, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand.
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
出版信息
Trans R Soc Trop Med Hyg. 2017 Apr 1;111(4):185-187. doi: 10.1093/trstmh/trx031.
BACKGROUND
Little is known about the involvement of the human gut in carriage and disease associated with Burkholderia pseudomallei, the cause of melioidosis.
METHODS
A hospital-based study was conducted in Northeast Thailand to culture stools or rectal swabs from patients with melioidosis, stools from controls with non-infectious diseases, and gastric biopsies from patients undergoing routine endoscopic investigation.
RESULTS AND CONCLUSION
B. pseudomallei was isolated from 9/83 (11%) stools and 9/58 (16%) rectal swabs from 141 patients with melioidosis. All stools from 244 control patients and 799 gastric biopsies from 395 patients with no evidence of melioidosis were culture negative for B. pseudomallei. It is not uncommon for melioidosis patients to shed B. pseudomallei in stool. Colonization of the gut of individuals without signs and symptoms of melioidosis may be rare.
背景
关于人类肠道在与类鼻疽病原体——伯克霍尔德菌属假鼻疽杆菌相关的携带和疾病中的作用，人们了解甚少。
方法
在泰国东北部开展了一项基于医院的研究，对类鼻疽患者的粪便或直肠拭子、患有非感染性疾病的对照者的粪便以及接受常规内镜检查患者的胃活检样本进行培养。
结果与结论
从141例类鼻疽患者的9/83份（11%）粪便和9/58份（16%）直肠拭子中分离出假鼻疽伯克霍尔德菌。244例对照患者的所有粪便以及395例无类鼻疽证据患者的799份胃活检样本经培养，假鼻疽伯克霍尔德菌均为阴性。类鼻疽患者粪便中排出假鼻疽伯克霍尔德菌的情况并不少见。没有类鼻疽体征和症状的个体肠道定植可能很少见。
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