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新诊断的阻塞性睡眠呼吸暂停与2型糖尿病

Newly diagnosed obstructive sleep apnoea and type 2 diabetes mellitus.

作者信息

Jacobsen Anne Roed, Eriksen Freja, Thorup Line, Skødeberg Lykke Bennedsen, Holm Jonas Peter Yde, Hansen Klavs Wörgler

出版信息

Dan Med J. 2017 Jul;64(7).

Abstract

INTRODUCTION

Obstructive sleep apnoea (OSA) is frequent in type 2 diabetes mellitus (DM) and is seen in 12-30% of patients with newly diagnosed OSA according to previous studies. Our aim was to determine the referral pattern and prevalence of patients with self-reported type 2 DM in a Danish cohort of patients with newly diagnosed OSA. Furthermore, we compared clinical data related to the sleep disorder in patients with and without type 2 DM and different OSA severities.

METHODS

This retrospective observational study was based on data from a cohort including all patients offered continuous positive airway pressure therapy in the course of a 14-month period after being referred to a sleep disorders clinic.

RESULTS

A total of 54 of 696 (7.8%) patients had type 2 DM. The majority of the patients in the type 2 DM group were referred from a general practitioner and only 8% from diabetes clinics. BMI, age and cardiovascular morbidity in type 2 DM patients were significantly higher than in the group without diabetes, while the Epworth Sleepiness Scale (ESS) score, the Apnea Hypopnea Index (AHI) and the Oxygen Desaturation Index (ODI) were not statistically different. Daytime sleepiness was similar in patients with mild-to-moderate compared with severe OSA.

CONCLUSIONS

AHI, ESS and ODI were similar in type 2 DM and the non-diabetic group. The prevalence of type 2 DM was lower than expected. Attention of healthcare providers to the association between type 2 DM and OSA is needed.

FUNDING

The study was funded by the Central Region Denmark Region Research Fund.

TRIAL REGISTRATION

not relevant.

摘要

引言

阻塞性睡眠呼吸暂停(OSA)在2型糖尿病(DM)患者中很常见,根据以往研究,新诊断的OSA患者中有12% - 30%患有该病。我们的目的是确定丹麦新诊断的OSA患者队列中自我报告的2型糖尿病患者的转诊模式和患病率。此外,我们比较了患有和未患有2型糖尿病以及不同OSA严重程度的患者与睡眠障碍相关的临床数据。

方法

这项回顾性观察性研究基于一个队列的数据,该队列包括在被转诊至睡眠障碍诊所后的14个月内接受持续气道正压通气治疗的所有患者。

结果

696名患者中有54名(7.8%)患有2型糖尿病。2型糖尿病组中的大多数患者是由全科医生转诊的,只有8%是由糖尿病诊所转诊的。2型糖尿病患者的体重指数、年龄和心血管疾病发病率显著高于无糖尿病组,而爱泼华嗜睡量表(ESS)评分、呼吸暂停低通气指数(AHI)和氧饱和度下降指数(ODI)在统计学上没有差异。轻度至中度OSA患者与重度OSA患者的日间嗜睡情况相似。

结论

2型糖尿病组和非糖尿病组的AHI、ESS和ODI相似。2型糖尿病的患病率低于预期。医疗保健提供者需要关注2型糖尿病与OSA之间的关联。

资助

该研究由丹麦中部地区研究基金资助。

试验注册

不相关。

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