Steenerson Kristen, Starling Amaal Jilani
Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, Arizona 85013, USA.
Neurology, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, Arizona 85054, USA.
Neurol Clin. 2017 Aug;35(3):403-408. doi: 10.1016/j.ncl.2017.03.011. Epub 2017 May 30.
Concussion pathophysiology is complicated and involves numerous mechanisms, including excessive neurotransmitter release, metabolic derangements, neuroinflammation, cerebral blood flow changes, and axonal disruption. The initial biomechanical impact in a concussion results in abnormal function at the cellular level, which initiates a cascade of events that leads to microstructural changes and, in the minority of cases, more persistent, permanent damage.
脑震荡的病理生理学很复杂，涉及众多机制，包括神经递质过度释放、代谢紊乱、神经炎症、脑血流变化和轴突中断。脑震荡中的初始生物力学冲击会导致细胞水平的功能异常，引发一系列事件，进而导致微观结构变化，在少数情况下，会造成更持久的永久性损伤。
