脑震荡的分子病理生理学
The Molecular Pathophysiology of Concussion.
作者信息
Howell David R, Southard Julia
机构信息
Sports Medicine Center, Children's Hospital Colorado, 13123 East 16th Avenue, B060, Aurora, CO 80045, USA; Department of Orthopedics, University of Colorado School of Medicine, Aurora, CO, USA.
Sports Medicine Center, Children's Hospital Colorado, 13123 East 16th Avenue, B060, Aurora, CO 80045, USA; Department of Psychology and Neuroscience, Regis University, 3333 Regis Boulevard, Denver, CO 80221, USA.
出版信息
Clin Sports Med. 2021 Jan;40(1):39-51. doi: 10.1016/j.csm.2020.08.001.
Abstract
After a concussion, a series of complex, overlapping, and disruptive events occur within the brain, leading to symptoms and behavioral dysfunction. These events include ionic shifts, damaged neuronal architecture, higher concentrations of inflammatory chemicals, increased excitatory neurotransmitter release, and cerebral blood flow disruptions, leading to a neuronal crisis. This review summarizes the translational aspects of the pathophysiologic cascade of postconcussion events, focusing on the role of excitatory neurotransmitters and ionic fluxes, and their role in neuronal disruption. We review the relationship between physiologic disruption and behavioral alterations, and proposed treatments aimed to restore the balance of disrupted processes.
摘要
脑震荡后，大脑内会发生一系列复杂、重叠且具有破坏性的事件，导致症状和行为功能障碍。这些事件包括离子转移、神经元结构受损、炎症化学物质浓度升高、兴奋性神经递质释放增加以及脑血流中断，进而引发神经元危机。本综述总结了脑震荡后事件病理生理级联反应的转化方面，重点关注兴奋性神经递质和离子通量的作用，以及它们在神经元破坏中的作用。我们回顾了生理紊乱与行为改变之间的关系，并提出了旨在恢复被破坏过程平衡的治疗方法。
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