Zhao Wenpeng, Qian Huiming, Zhang Ruisan, Gao Xingchun, Gou Xingchun
College of Clinical Medicine & Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Central Nervous System Disease and School of Basic Medical Sciences, Xi'an Medical University, Xi'an, China.
College of Clinical Medicine & Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Central Nervous System Disease and School of Basic Medical Sciences, Xi'an Medical University, Xi'an, China.
Med Hypotheses. 2017 Jul;104:25-29. doi: 10.1016/j.mehy.2017.05.012. Epub 2017 May 12.
Cancer is one of the most serious diseases that endanger human health in the world today, and the incidence and mortality of cancer increases year by year. Invasion and metastasis is the most prominent feature of malignant tumors, but also becomes the primary factor of threatening patient's health. Tumor cell invasion and metastasis which closely related to the dynamic changes of the cytoskeleton is an important factor influencing the survival of patients. Therefore, inhibition of tumor cell invasion and metastasis is a key strategy for the treatment of cancer. MACF1 is a microtubule microfilament cross-linking factor that plays an important role in cell polarization, cell migration, and maintenance of tissue integrity. A lot of studies have shown that microRNAs play an important role in tumorigenesis, invasion and metastasis. Therefore, we propose the following scientific assumptions: MACF1, an important molecule in adjusting the invasion and metastasis of tumor cells, regulates microfilaments, microtubules participating in cytoskeleton dynamics to promote malignant tumor cell migration and invasion; MicroRNA targeting MACF1 can decrease the expression of MACF1 and thus disrupt the dynamic balance of microtubule or microfilaments as an effective way to inhibit the invasion and metastasis of tumor cells. So we can use it as a new target for clinical early diagnosis and treatment of malignant tumor invasion and metastasis.
癌症是当今世界上危害人类健康最严重的疾病之一，且癌症的发病率和死亡率逐年上升。侵袭和转移是恶性肿瘤最显著的特征，也是威胁患者健康的首要因素。肿瘤细胞侵袭和转移与细胞骨架的动态变化密切相关，是影响患者生存的重要因素。因此，抑制肿瘤细胞侵袭和转移是癌症治疗的关键策略。MACF1是一种微管微丝交联因子，在细胞极化、细胞迁移和维持组织完整性方面发挥重要作用。大量研究表明，微小RNA在肿瘤发生、侵袭和转移中起重要作用。因此，我们提出以下科学假设：MACF1作为调节肿瘤细胞侵袭和转移的重要分子，通过调节参与细胞骨架动态变化的微丝、微管来促进恶性肿瘤细胞迁移和侵袭；靶向MACF1的微小RNA可降低MACF1的表达，从而破坏微管或微丝的动态平衡，作为抑制肿瘤细胞侵袭和转移的有效途径。因此，我们可以将其作为临床早期诊断和治疗恶性肿瘤侵袭和转移的新靶点。
