环氧乙烷诱导的IgE抗体与透析患者症状的关联。

Association of ethylene-oxide-induced IgE antibodies with symptoms in dialysis patients.

作者信息

Rumpf K W, Seubert S, Seubert A, Lowitz H D, Valentin R, Rippe H, Ippen H, Scheler F

出版信息

Lancet. 1985;2(8469-70):1385-7. doi: 10.1016/s0140-6736(85)92555-3.

Abstract

IgE-type antibodies to human serum albumin/ethylene oxide conjugates were determined in 153 patients (140 unselected, 13 selected for presence of eosinophilia) on regular dialysis treatment by radioallergosorbent test (RAST) techniques. In 10.7% of unselected patients and 30.8% of selected patients, RAST values suggested ethylene oxide sensitisation. High RAST values were commonly associated with anaphylactoid reactions during dialysis and with chronic asthma. Ethylene oxide antibodies should be sought routinely in patients presenting with these symptoms and the necessity of ethylene oxide sterilisation of disposable dialysis equipment should be re-evaluated.

摘要

采用放射变应原吸附试验（RAST）技术，对153例接受定期透析治疗的患者（140例为未经过挑选的，13例因存在嗜酸性粒细胞增多症而入选）检测了针对人血清白蛋白/环氧乙烷结合物的IgE型抗体。在未经过挑选的患者中，10.7%的患者以及在入选患者中30.8%的患者，RAST值提示环氧乙烷致敏。高RAST值通常与透析期间的类过敏反应以及慢性哮喘有关。对于出现这些症状的患者，应常规检测环氧乙烷抗体，并且应重新评估一次性透析设备环氧乙烷灭菌的必要性。