将福美双和双硫仑重新用于治疗耐多药金黄色葡萄球菌感染的抗菌药物。
Repurposing Thiram and Disulfiram as Antibacterial Agents for Multidrug-Resistant Staphylococcus aureus Infections.
机构信息
Department of Pharmaceutical Science and Research, School of Pharmacy, and Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA
出版信息
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.00898-17. Print 2017 Sep.
Abstract
Thiram and disulfiram were evaluated as antibacterial agents against multidrug-resistant Against a 30-member panel comprised of vancomycin-susceptible, vancomycin-intermediate, and vancomycin-resistant strains, the MIC values of the respective test agents were 4 and 16 μg/ml. Additional analyses revealed that thiram and disulfiram are rapid-acting bacteriostatic agents with narrow, Gram-positive-bacterium spectrum activity. Synergy studies further determined that disulfiram increases the vancomycin susceptibility of three clinical vancomycin-resistant strains , thus establishing a potential use in combination therapy.
摘要
四亚甲基二砜四胺和双硫仑被评估为抗耐多药革兰阳性菌的抗菌药物。在一个由万古霉素敏感、中介和耐药 30 株菌组成的专家组中，相应测试药物的 MIC 值分别为 4 和 16 μg/ml。进一步的分析表明，四亚甲基二砜四胺和双硫仑是快速作用的抑菌剂，具有窄谱、革兰阳性菌活性。协同作用研究进一步确定，双硫仑增加了三种临床耐万古霉素的 菌株对万古霉素的敏感性，从而为联合治疗提供了潜在用途。
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