Turos Edward
Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, CHE 205, Tampa, FL 33620, USA.
Pathogens. 2025 Jun 24;14(7):628. doi: 10.3390/pathogens14070628.
Pathogenic bacteria such as the drug-resistant strains of dominate our medical and environmental landscape, causing hundreds of thousands of deaths from infections and life-threatening complications following surgeries. The availability of antibiotics and treatment protocols to control these microbes are becoming increasingly more limited as antibiotic resistance becomes more prevalent. In this article, a new family of small molecules referred to as -organothio β-lactams is presented that have unique features and a mode of action against these pathogenic microbes, including multi-drug resistant strains, that may offer new options to address these concerns. This review gives an overview of the initial discovery, exploration and ongoing development of these synthetic antibacterial agents, with a focus on their unique properties and capabilities that provide fresh opportunities for combating pathogenic bacteria.
诸如耐药菌株之类的致病细菌主导着我们的医疗和环境领域，导致因感染以及手术后危及生命的并发症而造成数十万人死亡。随着抗生素耐药性日益普遍，用于控制这些微生物的抗生素和治疗方案越来越有限。在本文中，介绍了一类新的小分子，称为有机硫代β-内酰胺，它们具有独特的特性和针对这些致病微生物（包括多重耐药菌株）的作用方式，这可能为解决这些问题提供新的选择。本综述概述了这些合成抗菌剂的最初发现、探索和持续开发，重点关注它们的独特性质和能力，这些为对抗致病细菌提供了新的机会。
