产 NDM-1、IMP-4 和 KPC-2 碳青霉烯酶的解鸟氨酸克雷伯菌的首次报告。
First Report of Klebsiella oxytoca Strain Simultaneously Producing NDM-1, IMP-4, and KPC-2 Carbapenemases.
机构信息
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
UCD-Centre for Food Safety, School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Dublin, Ireland.
出版信息
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.00877-17. Print 2017 Sep.
Abstract
The nucleotide sequences of five plasmids from one isolate were determined using the PacBio RS II system. Plasmid analysis revealed that was carried on an IncX3 plasmid. The and genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on a isolate.
摘要
使用 PacBio RS II 系统测定了来自一个分离株的五个质粒的核苷酸序列。质粒分析表明，该分离株携带 IncX3 质粒。blaNDM-1 和 blaIMP-4 基因分别位于 IncN 和 IncP-6 质粒上。比较序列分析突出了携带碳青霉烯酶的质粒在不同肠杆菌种之间的成功传播。据我们所知，我们首次报告了在一个分离株上同时产生 NDM-1、KPC-2 和 IMP-4 碳青霉烯酶。
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