Row Sindhu, Santandreu Ana, Swartz Daniel D, Andreadis Stelios T
Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY 14260-4200, USA.
Angiograft LLC, Amherst NY.
Technology (Singap World Sci). 2017 Mar;5(1):13-20. doi: 10.1142/S2339547817400015. Epub 2017 Mar 31.
Recent advances in vascular tissue engineering have led to the development of cell-free grafts that are available off-the-shelf for on demand surgery. Challenges associated with cell-based technologies including cell sourcing, cell expansion and long-term bioreactor culture motivated the development of completely cell-free vascular grafts. These are based on decellularized arteries, decellularized cultured cell-based tissue engineered grafts or biomaterials functionalized with biological signals that promote tissue regeneration. Clinical trials undertaken to demonstrate the applicability of these grafts are also discussed. This comprehensive review summarizes recent developments in vascular graft technologies, with potential applications in coronary artery bypass procedures, lower extremity bypass, vascular injury and trauma, congenital heart diseases and dialysis access shunts, to name a few.
血管组织工程学的最新进展促使了即用型无细胞移植物的开发，可随时用于按需手术。基于细胞的技术所面临的挑战，包括细胞来源、细胞扩增和长期生物反应器培养，推动了完全无细胞血管移植物的发展。这些移植物基于去细胞化动脉、去细胞化的基于培养细胞的组织工程移植物或用促进组织再生的生物信号功能化的生物材料。文中还讨论了为证明这些移植物的适用性而进行的临床试验。这篇全面的综述总结了血管移植物技术的最新进展，其潜在应用包括冠状动脉搭桥手术、下肢搭桥、血管损伤和创伤、先天性心脏病以及透析通路分流等。
