Yu Yaling, Alkhawaji Ali, Ding Yuqiang, Mei Jin
Department of Anatomy, Wenzhou Medical University, Wenzhou, China.
Institute of Bioscaffold Transplantation and Immunology, Wenzhou Medical University, Wenzhou, China.
Oncotarget. 2016 Sep 6;7(36):58671-58683. doi: 10.18632/oncotarget.10945.
Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure. Yet, the clinical application is limited by the shortage of donor organs and the need for lifelong immunosuppression, highlighting the importance of developing effective therapeutic strategies. In the field of regenerative medicine, various regenerative technologies have lately been developed using various biomaterials to address these limitations. Decellularized scaffolds, derived mainly from various non-autologous organs, have been proved a regenerative capability in vivo and in vitro and become an emerging treatment approach. However, this regenerative capability varies between scaffolds as a result of the diversity of anatomical structure and cellular composition of organs used for decellularization. Herein, recent advances in scaffolds based on organ regeneration in vivo and in vitro are highlighted along with aspects where further investigations and analyses are needed.
同种异体器官移植仍然是终末期器官衰竭的最终解决方案。然而，临床应用受到供体器官短缺和终身免疫抑制需求的限制，这凸显了开发有效治疗策略的重要性。在再生医学领域，最近已经开发了各种再生技术，使用各种生物材料来解决这些限制。主要来自各种非自体器官的脱细胞支架已被证明在体内和体外具有再生能力，并成为一种新兴的治疗方法。然而，由于用于脱细胞的器官的解剖结构和细胞组成的多样性，这种再生能力在不同支架之间有所不同。本文重点介绍了基于体内和体外器官再生的支架的最新进展，以及需要进一步研究和分析的方面。
