Kuhar M J, Unnerstall J R, De Souza E B
NIDA Res Monogr. 1985;62:1-12.
In the past decade, substantial advances in receptor mapping have been made. It is now as feasible to carry out receptor localizations as it is to carry out neurotransmitter localizations. A great deal of data has accumulated on various technical procedures and it is clear that significant problems occur with tritiated ligands. These problems involve different autoradiographic efficiencies in tissue regions, and steps must be taken to either correct for these different efficiencies or to eliminate them. It seems that I125-labeled ligands will become more and more important in the field.
在过去十年中，受体定位技术取得了重大进展。如今，进行受体定位与进行神经递质定位一样可行。关于各种技术程序已经积累了大量数据，并且很明显，氚标记配体存在重大问题。这些问题涉及组织区域中不同的放射自显影效率，必须采取措施来校正这些不同的效率或消除它们。看来，碘-125标记的配体在该领域将变得越来越重要。
