Ekker M, Sourkes T L
Neuropharmacology. 1985 Nov;24(11):1063-6. doi: 10.1016/0028-3908(85)90192-3.
The induction of two adrenomedullary enzymes, ornithine decarboxylase and tyrosine hydroxylase, by apomorphine was studied in rats receiving dopamine antagonists known to by specific in their site of action. Metoclopramide, a drug that acts predominantly on the A9 dopamine system, was effective in blocking the induction of the two enzymes by apomorphine. Thioridazine and clozapine, two antipsychotic drugs that act preferentially on the A10 dopamine systems, did not impair this induction and possibly potentiated it. The results suggest that the site of action of apomorphine responsible for the induction of adrenomedullary ornithine decarboxylase and tyrosine hydroxylase is located in the striatum.
在接受已知作用位点具有特异性的多巴胺拮抗剂的大鼠中，研究了阿扑吗啡对两种肾上腺髓质酶（鸟氨酸脱羧酶和酪氨酸羟化酶）的诱导作用。甲氧氯普胺是一种主要作用于A9多巴胺系统的药物，能有效阻断阿扑吗啡对这两种酶的诱导。硫利达嗪和氯氮平是两种优先作用于A10多巴胺系统的抗精神病药物，它们不会削弱这种诱导作用，甚至可能增强它。结果表明，阿扑吗啡诱导肾上腺髓质鸟氨酸脱羧酶和酪氨酸羟化酶的作用位点位于纹状体。
