Balsak Selahattin, Kaydu Ayhan, Erdem Seyfettin, Fuat Alakus M, Ozkurt Zeynep Gursel
Diyarbakır Research and Education Hospital, Diyarbakir, Turkey.
Department of Anesthesiology, Diyarbakır Selahaddini Eyyübi State Hospital, 21100, Diyarbakir, Turkey.
Int Ophthalmol. 2018 Aug;38(4):1583-1589. doi: 10.1007/s10792-017-0626-z. Epub 2017 Jul 3.
To compare the efficacy of the fixed combination of brimonidine-timolol (FCBT) and the fixed combination of brinzolamide-timolol (FCBZT) treatments for elevated intraocular pressure (IOP) after phacoemulsification cataract surgery.
A randomised, prospective, double-blinded study was conducted on 277 eyes of 257 patients who underwent phacoemulsification cataract surgery. Patients were divided into three groups based on the medication administered after cataract surgery as follows: FCBT, FCBZT and a control group where no antiglaucoma medications were used. IOP was recorded at preoperative and postoperative hours 6 and 24 and days 3 and 5.
No statistical differences were observed among the groups regarding age, sex and baseline IOP levels (p > 0.05). Mean IOP levels were significantly lower in the treatment groups than in the control group at postoperative hours 6 and 24 and days 3 and 5 (p < 0.001). Administration of one drop of FCBT or FCBZT demonstrated similar effects on preventing IOP spikes within 24 h of phacoemulsification cataract surgery. FCBZT more effectively lowered IOP than FCBT at days 3 and 5 (p < 0.05).
We demonstrate that the postoperative administration of FCBT or FCBZT is effective in lowering IOP after phacoemulsification cataract surgery; FCBZT more effectively lowered IOP than FCBT at postoperative days 3 and 5.
比较溴莫尼定 - 噻吗洛尔固定复方制剂（FCBT）和布林佐胺 - 噻吗洛尔固定复方制剂（FCBZT）治疗白内障超声乳化术后眼压升高的疗效。
对257例行白内障超声乳化手术患者的277只眼进行随机、前瞻性、双盲研究。根据白内障手术后使用的药物将患者分为三组：FCBT组、FCBZT组和未使用抗青光眼药物的对照组。在术前、术后6小时和24小时以及术后3天和5天记录眼压。
三组在年龄、性别和基线眼压水平方面无统计学差异（p > 0.05）。在术后6小时和24小时以及术后3天和5天，治疗组的平均眼压水平显著低于对照组（p < 0.001）。在白内障超声乳化手术后24小时内，滴用一滴FCBT或FCBZT对预防眼压峰值显示出相似的效果。在术后3天和5天，FCBZT降低眼压的效果比FCBT更显著（p < 0.05）。
我们证明白内障超声乳化术后给予FCBT或FCBZT可有效降低眼压；在术后3天和5天，FCBZT降低眼压的效果比FCBT更显著。
