超声乳化术后固定联合应用溴莫尼定和噻吗洛尔对眼压的影响。

Effect of a fixed brimonidine-timolol combination on intraocular pressure after phacoemulsification.

机构信息

Department of Ophthalmology, University of Patras, Medical School, Patras, Greece.

出版信息

J Cataract Refract Surg. 2011 Feb;37(2):279-83. doi: 10.1016/j.jcrs.2010.08.046.

DOI:10.1016/j.jcrs.2010.08.046

PMID:21241910

Abstract

PURPOSE

To evaluate the effect of a fixed combination of brimonidine-timolol on intraocular pressure (IOP) after phacoemulsification cataract surgery.

SETTING

Department of Ophthalmology, Patras University Hospital, Patras, Greece.

DESIGN

Prospective randomized comparative case series.

METHODS

Patients scheduled for phacoemulsification were randomly assigned to 1 of 2 groups. The treatment group received 1 drop of brimonidine-timolol fixed combination immediately after surgery, and the control group received no treatment. The IOP was measured preoperatively and 6, 12, and 24 hours postoperatively.

RESULTS

The treatment group comprised 28 eyes and the control group, 30 eyes. The mean IOP increased by 0.14 mm Hg ± 3.88 (SD) (P = .88) in the treatment group and increased by 2.8 ± 5.01 mm Hg (P = .007) in the control group. Twelve hours after surgery, the mean IOP decreased by -0.57 ± 3.82 mm Hg (P = .49) in the treatment group and increased by 2.20 ± 4.56 mm Hg (P = .009) in the control group. Twenty-four hours after surgery, the mean IOP decreased by -1.57 ± 2.30 mm Hg (P=.012) in the treatment group and increased by 0.86 ± 4.21 mm Hg (P = .175) in the control group. The mean IOP change between the 2 study groups 6, 12, and 24 hours postoperatively was statistically significantly different (P = .015, P = .006, and P = .003; respectively).

CONCLUSION

The fixed brimonidine-timolol combination effectively reduced IOP 6, 12, and 24 hours after phacoemulsification cataract surgery.

摘要

目的

评估布林佐胺-噻吗洛尔固定合剂对白内障超声乳化术后眼内压（IOP）的影响。

地点

希腊派拉思大学医院眼科。

设计

前瞻性随机对照病例系列研究。

方法

接受白内障超声乳化术的患者随机分为 2 组。治疗组术后即刻给予 1 滴布林佐胺-噻吗洛尔固定合剂，对照组不给予任何治疗。术前及术后 6、12 和 24 小时测量 IOP。

结果

治疗组 28 只眼，对照组 30 只眼。治疗组的平均眼压升高 0.14mmHg±3.88（SD）（P =.88），对照组升高 2.8±5.01mmHg（P =.007）。术后 12 小时，治疗组平均眼压下降-0.57±3.82mmHg（P =.49），对照组升高 2.20±4.56mmHg（P =.009）。术后 24 小时，治疗组平均眼压下降-1.57±2.30mmHg（P=.012），对照组升高 0.86±4.21mmHg（P =.175）。术后 6、12 和 24 小时，2 组间的平均眼压变化差异均有统计学意义（P =.015、P =.006 和 P =.003）。