用[3H]氟奋乃静标记的大鼠新纹状体匀浆中D-1多巴胺受体的特性
Characteristics of D-1 dopamine receptors labelled by [3H]fluphenazine in homogenates of rat neostriatum.
作者信息
Cincotta M, de Vries D J, Beart P M
出版信息
Neurosci Lett. 1985 Oct 24;61(1-2):85-9. doi: 10.1016/0304-3940(85)90405-7.
PMID:2867505
Abstract
The properties of the site labelled by [3H]fluphenazine in membranes prepared from the rat neostriatum were examined using radioligand binding methodology. Binding of [3H]fluphenazine was rapid, saturable and of high affinity (K4 = 0.4 nM). Drug displacement experiments demonstrated that the site labelled by [3H]fluphenazine possessed pharmacological characteristics consistent with those of a D-1 dopamine receptor.
摘要
利用放射性配体结合方法，研究了用[³H]氟奋乃静标记的大鼠新纹状体膜位点的特性。[³H]氟奋乃静的结合迅速、可饱和且具有高亲和力（Kd = 0.4 nM）。药物置换实验表明，用[³H]氟奋乃静标记的位点具有与D-1多巴胺受体一致的药理学特性。
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