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循环血管细胞黏附分子-1在无已知糖尿病的冠心病和心脏综合征X患者中的差异表达。

Differential expression of circulating vascular cell adhesion molecule-1 in subjects with coronary artery disease and cardiac syndrome X without known diabetes mellitus.

作者信息

Liang Kae-Woei, Sheu Wayne H-H, Lee Wen-Jane, Lee Wen-Lieng, Fu Chia-Po, Wang Jun-Sing

机构信息

a Cardiovascular Center , Taichung Veterans General Hospital , Taichung , Taiwan.

b School of Medicine , National Yang Ming University , Taipei , Taiwan.

出版信息

Biomarkers. 2017 Dec;22(8):798-804. doi: 10.1080/1354750X.2017.1351003. Epub 2017 Jul 18.

DOI:10.1080/1354750X.2017.1351003
PMID:28675064
Abstract

CONTEXT

Inflammation is one of the mechanisms underlying cardiac syndrome X (CSX).

OBJECTIVES

Few studies have compared the expression of inflammatory or adhesion molecules between coronary artery disease (CAD) versus CSX.

MATERIALS AND METHODS

Ninety-two CSX and 145 CAD subjects without known diabetes mellitus underwent coronary angiogram for angina.

RESULTS

Vascular cell adhesion molecule (VCAM)-1 (median, 507 versus 431 ng/ml, p = 0.001) was significantly higher in the CAD group. In the binary regression, VCAM-1 was a significant differential factor for CAD versus CSX.

DISCUSSION AND CONCLUSION

Adhesion molecules might be implicated in the differential expression of macro versus microvascular coronary disease.

TRIAL REGISTRATION NUMBER

NCT01198730 at https://clinicaltrials.gov.

摘要

背景

炎症是心脏X综合征（CSX）的潜在机制之一。

目的

很少有研究比较冠心病（CAD）与CSX之间炎症或黏附分子的表达。

材料与方法

92例CSX患者和145例无糖尿病的CAD患者因心绞痛接受冠状动脉造影。

结果

CAD组血管细胞黏附分子（VCAM）-1（中位数，507对431 ng/ml，p = 0.001）显著更高。在二元回归中，VCAM-1是CAD与CSX的显著差异因素。

讨论与结论

黏附分子可能与冠状动脉大血管与微血管疾病的差异表达有关。

试验注册号

https://clinicaltrials.gov上的NCT01198730。

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