缓激肽及相关肽在心血管系统的中枢控制中作用

Bradykinin and related peptides in central control of the cardiovascular system.

作者信息

Diz D I

出版信息

Peptides. 1985;6 Suppl 2:57-64. doi: 10.1016/0196-9781(85)90135-4.

Abstract

The evidence for a brain kallikrein-kinin system and for the possible role for kinins in brain control of the cardiovascular system are reviewed. All components of the kallikrein-kinin system are present in brain and kinins have a variety of cardiovascular actions of central origin following peripheral, intracerebroventricular or brain parenchymal administration. How components of the brain kallikrein-kinin system are regulated or even whether they function as a system remains to be established. However, bradykinin does fulfill several of the criteria necessary for establishing a substance as a neurotransmitter and these are discussed.

摘要

本文综述了脑激肽释放酶 - 激肽系统的证据以及激肽在大脑对心血管系统控制中可能发挥的作用。激肽释放酶 - 激肽系统的所有成分都存在于大脑中，在外周、脑室内或脑实质给药后，激肽具有多种源自中枢的心血管作用。脑激肽释放酶 - 激肽系统的成分如何被调节，甚至它们是否作为一个系统发挥作用仍有待确定。然而，缓激肽确实满足了将一种物质确立为神经递质所需的几个标准，本文对此进行了讨论。