Fitzgibbon W R, Ploth D W, Margolius H S
Department of Medicine, Medical University of South Carolina, Charleston.
Curr Opin Nephrol Hypertens. 1993 Mar;2(2):283-90. doi: 10.1097/00041552-199303000-00016.
During the past year, a number of significant publications have provided data that clearly establish the basis for the important role of the tissue kallikrein-kinin system in cardiovascular control and renal function. These publications include a report of advances in techniques for system component measurement, reports of the localization of central bradykinin receptors and an alteration in the sensitivity of the central bradykinin system in hypertension, and a description of the effects of new kinin receptor antagonists on our understanding of endogenous and exogenous kinin-induced vasorelaxation and its possible alteration in hypertension. Several significant reports describe the potentiation of endogenous kinin action by kininase inhibitors and establish the important interaction between kininase activity and kinin control of blood pressure.
在过去的一年里，一些重要的出版物提供的数据明确地确立了组织激肽释放酶 - 激肽系统在心血管控制和肾功能中发挥重要作用的基础。这些出版物包括关于系统成分测量技术进展的报告、中枢缓激肽受体定位的报告以及高血压患者中枢缓激肽系统敏感性的改变，还有关于新型激肽受体拮抗剂对我们理解内源性和外源性激肽诱导的血管舒张及其在高血压中可能改变的影响的描述。几份重要报告描述了激肽酶抑制剂对内源性激肽作用的增强，并确立了激肽酶活性与激肽血压控制之间的重要相互作用。
