从海洋生物中分离出的抗肿瘤生物活性肽。

Antitumour bioactive peptides isolated from marine organisms.

作者信息

Xing Haibo, Tong Mengting, Jiang Nanyu, Zhang Xiaomin, Hu Hong, Pan Hongming, Li Da

机构信息

Department of ICU, Xiasha Campus, Sir Run Run Shaw Hospital Affiliated to Zhejiang University, School of Medicine, Hangzhou, China.

Department of Medical Oncology, Sir Run Run Shaw Hospital Affiliated to Zhejiang University, School of Medicine, Hangzhou, China.

出版信息

Clin Exp Pharmacol Physiol. 2017 Nov;44(11):1077-1082. doi: 10.1111/1440-1681.12808.

DOI:10.1111/1440-1681.12808

PMID:28675498

Abstract

Marine organisms are an important source of antitumour active substances. Thus, pharmaceutical research in recent years has focused on exploring new antitumour drugs derived from marine organisms, and, many peptide drugs with strong antitumour activities have been successfully extracted. Based on different mechanisms, this paper reviews the research on several typical antitumour bioactive peptides in marine drugs and the latest progress therein. Additionally, the development prospects for these antitumour bioactive peptide-based drugs are discussed so as to provide a reference for future research in this field.

摘要

海洋生物是抗肿瘤活性物质的重要来源。因此，近年来药物研究聚焦于探索源自海洋生物的新型抗肿瘤药物，并且，许多具有强大抗肿瘤活性的肽类药物已被成功提取。基于不同机制，本文综述了海洋药物中几种典型抗肿瘤生物活性肽的研究及其最新进展。此外，还讨论了这些基于抗肿瘤生物活性肽的药物的发展前景，以便为该领域的未来研究提供参考。