Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
Department of Radiation Sciences, Faculty of Applied Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.
Int J Mol Sci. 2022 Jan 27;23(3):1445. doi: 10.3390/ijms23031445.
Bioactive peptides are a group of biological molecules that are normally buried in the structure of parent proteins and become active after the cleavage of the proteins. Another group of peptides is actively produced and found in many microorganisms and the body of organisms. Today, many groups of bioactive peptides have been marketed chemically or recombinantly. This article reviews the various production methods and sources of these important/ubiquitous and useful biomolecules. Their applications, such as antimicrobial, antihypertensive, antioxidant activities, blood-lipid-lowering effect, opioid role, antiobesity, ability to bind minerals, antidiabetic, and antiaging effects, will be explored. The types of pathways proposed for bioactive applications will be in the next part of the article, and at the end, the future perspectives of bioactive peptides will be reviewed. Reading this article is recommended for researchers interested in various fields of physiology, microbiology, biochemistry, and nanotechnology and food industry professionals.
生物活性肽是一组生物分子,它们通常埋藏在母体蛋白质的结构中,在蛋白质切割后变得活跃。另一组肽是在许多微生物和生物体中主动产生和发现的。如今,许多化学或重组的生物活性肽已上市。本文综述了这些重要/普遍且有用的生物分子的各种生产方法和来源。还探讨了它们的应用,如抗菌、降压、抗氧化活性、降血脂作用、阿片样作用、抗肥胖、结合矿物质的能力、抗糖尿病和抗衰老作用。生物活性应用的途径类型将在下一部分文章中提出,最后将回顾生物活性肽的未来前景。建议对生理学、微生物学、生物化学和纳米技术以及食品工业领域感兴趣的研究人员阅读本文。