Morley J E, Levine A S
Prog Clin Biol Res. 1985;192:293-300.
Many investigations have suggested that endogenous opioids are involved in the regulation of food ingestion. Pharmacological studies have clearly demonstrated that kappa opioid receptors play a role in the modulation of feeding. Dynorphin, a peptide which appears to be the endogenous ligand of the kappa receptor, is a potent stimulator of feeding and its levels in the central nervous system are altered under conditions associated with alterations in the feeding drive. The enhancement of feeding produced by dynorphin involves both the opioid and non-opioid portion of the molecule. These studies suggest that dynorphin is an endogenous stimulator of feeding.
许多研究表明内源性阿片肽参与食物摄取的调节。药理学研究已清楚表明κ阿片受体在进食调节中发挥作用。强啡肽是一种似乎是κ受体的内源性配体的肽，是进食的有效刺激物，并且在与进食驱动力改变相关的条件下其在中枢神经系统中的水平会发生变化。强啡肽产生的进食增强涉及该分子的阿片样物质和非阿片样物质部分。这些研究表明强啡肽是进食的内源性刺激物。
