Morley J E, Levine A S, Gosnell B A, Kneip J, Grace M
Physiol Behav. 1983 Nov;31(5):603-6.
Recent studies have suggested a role for the kappa opiate receptor and its endogenous ligand, dynorphin, in the central regulation of appetite. In this study we found that the ob/ob mouse was mildly resistant to the ability of three kappa agonists, viz, butorphanol, tifluadom, and ketocyclazocine to induce food intake. In addition, we could find no change in ir-dynorphin levels in 7 areas for the central nervous system. These findings do not provide evidence for a role of kappa opioid feeding system in the pathogenesis of obesity in the ob/ob mouse.
最近的研究表明，κ阿片受体及其内源性配体强啡肽在食欲的中枢调节中发挥作用。在本研究中，我们发现ob/ob小鼠对三种κ激动剂（即布托啡诺、替氟朵姆和酮环唑辛）诱导食物摄入的能力有轻度抗性。此外，我们未发现中枢神经系统7个区域的免疫反应性强啡肽水平有变化。这些发现并未为κ阿片类进食系统在ob/ob小鼠肥胖发病机制中的作用提供证据。
