Westlund K N
Prog Clin Biol Res. 1985;192:395-402.
The distribution of many peptides throughout the mammalian CNS has been described. This report will review immunocytochemically-defined non-opioid peptide systems in relation to the more established monoamine systems. Immunocytochemical localization, especially when combined with intraneuronal tracing techniques, provides information about possible interactions among neuronal systems including terminations associated with the cell bodies of other systems, common terminal fields, or co-localization within the same neurons. For example, many peptide and monoamine systems send parallel descending projections to the spinal cord. The origins of many of these spinal cord projections within specific brainstem nuclei are known and will be described. The elucidation of chemically defined anatomical connections within the central nervous system (CNS) is an immense but necessary undertaking in the understanding of CNS involvement in normal and abnormal physiological and behavioral processes.
许多肽在整个哺乳动物中枢神经系统中的分布已被描述。本报告将回顾免疫细胞化学定义的非阿片肽系统与更为成熟的单胺系统的关系。免疫细胞化学定位，特别是与神经元内追踪技术相结合时，可提供有关神经元系统之间可能相互作用的信息，包括与其他系统细胞体相关的终末、共同的终末场或同一神经元内的共定位。例如，许多肽和单胺系统向脊髓发出平行的下行投射。这些脊髓投射中许多在特定脑干核内的起源是已知的，并将予以描述。阐明中枢神经系统（CNS）内化学定义的解剖学连接是理解CNS参与正常和异常生理及行为过程的一项艰巨但必要的工作。
