Department of Neuroscience, IRCCS-Mario Negri Institute for Pharmacological Research, Milano, Italy.
University Hospital, Basel, Switzerland.
Epilepsia. 2017 Jul;58 Suppl 3:7-10. doi: 10.1111/epi.13780.
We report about the main topics presented during this meeting which was devoted to discuss the new emerging evidence for a role of immune- and inflammation-related mechanisms in various autoimmune and nonautoimmune forms of epilepsy. Major emphasis was given to novel immune/inflammatory mechanisms contributing to seizures and neurological comorbidities as well as to the discovery and validation of noninvasive biomarkers of brain inflammation which may be used to monitor epileptogenesis and predict the therapeutic effects of treatments. The key question was whether our scientific community is ready for the translation of the results of laboratory research to clinical studies, and how to best design clinical trials of anti-inflammatory drugs with potential disease-modifying effects.
我们报告了本次会议讨论的主要议题，这些议题集中于探讨免疫和炎症相关机制在各种自身免疫性和非自身免疫性癫痫形式中的新出现的作用。重点是探讨导致癫痫发作和神经合并症的新的免疫/炎症机制，以及发现和验证可用于监测癫痫发生和预测治疗效果的脑炎症无创生物标志物。关键问题是我们的科学界是否准备好将实验室研究的结果转化为临床研究，以及如何最好地设计具有潜在疾病修饰作用的抗炎药物的临床试验。
