Kiba Keisuke, Hirayama Akihide, Yoshikawa Motokiyo, Yamamoto Yutaka, Torimoto Kazumasa, Shimizu Nobutaka, Tanaka Nobumichi, Fujimoto Kiyohide, Uemura Hirotsugu
Department of Urology, Nara Hospital, Kindai University, Ikoma, Japan.
Department of Urology, Nara Medical University, Kashihara, Japan.
Low Urin Tract Symptoms. 2018 Sep;10(3):253-258. doi: 10.1111/luts.12176. Epub 2017 Jul 3.
To investigate whether or not the leg fluid displacement observed when moving from the standing to recumbent position at bedtime reduces the hours of undisturbed sleep (HUS).
Men aged 50 years or older who were hospitalized for urological diseases were investigated. Body water evaluation was performed three times with a bioelectric impedance method: (i) 17:00, (ii) 30 min after (short-term), and (iii) waking up (long-term). A frequency volume chart was used to evaluate the status of nocturnal urine production, and the factors affecting HUS were investigated.
A total of 50 patients (mean age: 68 years) were enrolled. Short-term changes in extracellular fluid (ECF in the legs showed a significant positive correlation with urine production per unit of time at the first nocturnal voiding (UFN/HUS) (r = 0.45, P = 0.01). In the comparison between patients who had <3 HUS vs. those who had ≥3 HUS, the <3 HUS group showed significantly greater short-term changes in leg fluid volume, night-time water intake (17:00-06:00), and UFN/HUS. Multivariate analysis to assess the risk factors for <3 HUS indicated UFN/HUS as a risk factor in the overall model, and short-term changes in leg ECF and night-time water intake as risk factors in the model that only considered factors before sleep.
Nocturnal leg fluid displacement may increase urine production leading up to first voiding after going to bed, and consequently, induce early awakening after falling asleep.
研究睡前从站立位转变为卧位时观察到的腿部液体转移是否会减少无干扰睡眠时长（HUS）。
对因泌尿系统疾病住院的50岁及以上男性进行研究。使用生物电阻抗法进行三次身体水分评估：（i）17:00，（ii）（短期）之后30分钟，以及（iii）醒来时（长期）。使用频率尿量图评估夜间尿液生成情况，并研究影响HUS的因素。
共纳入50例患者（平均年龄：68岁）。腿部细胞外液（ECF）的短期变化与首次夜间排尿时每单位时间的尿量（UFN/HUS）呈显著正相关（r = 0.45，P = 0.01）。在HUS<3小时的患者与HUS≥3小时的患者之间的比较中，HUS<3小时组的腿部液体量、夜间饮水量（17:00 - 06:00）和UFN/HUS的短期变化显著更大。评估HUS<3小时的危险因素的多变量分析表明，UFN/HUS是总体模型中的危险因素，而腿部ECF的短期变化和夜间饮水量是仅考虑睡眠前因素的模型中的危险因素。
夜间腿部液体转移可能会增加睡前至首次排尿前的尿量，从而导致入睡后过早醒来。
