Lambrinoudaki Irene, Kazani Aikaterini, Armeni Eleni, Rizos Demetrios, Augoulea Areti, Kaparos Georgios, Alexandrou Andreas, Georgiopoulos Georgios, Kanakakis Ioannis, Stamatelopoulos Kimon
a 2nd Department of Obstetrics and Gynecology , University of Athens, Aretaieio Hospital , Athens , Greece.
b Department of Therapeutics , University of Athens, Alexandra Hospital , Athens , Greece.
Gynecol Endocrinol. 2018 Jan;34(1):78-82. doi: 10.1080/09513590.2017.1344208. Epub 2017 Jul 4.
The menopause transition is associated with adverse changes in cardiometabolic risk factors. We aimed to examine the association of the metabolic syndrome (MS) and its features with indices of vascular structure and function in a population of asymptomatic postmenopausal women. A total of 473 informed-consenting, nondiabetic postmenopausal women were included in the study. The MS was defined according to the Joint Definition. We evaluated the association between the presence of MS and indices of vascular structure (carotid artery intima-media thickness (IMT); atherosclerotic plaques) and function (flow-mediated dilatation (FMD); pulse wave velocity (PWV)). The mean age of women was 56.4 ± 6.7 and the mean menopausal age was 7.91 ± 6.31. The MS was present in 17.3% of our population. Mean values of PWV increased linearly with the accumulation of features of the MS. IMT was higher in women with the MS compared to women without the MS (0.78 ± 0.12 mm vs. 0.74 ± 0.11, p = .003). Multivariate analysis showed that the presence of the MS was independently associated with common carotid artery IMT (b = 0.149, p = .001), PWV (b = 0.114, p = .012) as well as central systolic and diastolic blood pressure (b = 0.293, p < .001 and b = 0.163, p < .001 respectively). The presence of the MS is associated with subclinical atherosclerosis already in the first postmenopausal decade of this sample of asymptomatic, nondiabetic women. Additional evidence is required to support the causative effect of these associations.
绝经过渡与心血管代谢危险因素的不良变化相关。我们旨在研究无症状绝经后女性人群中代谢综合征（MS）及其特征与血管结构和功能指标之间的关联。共有473名签署知情同意书的非糖尿病绝经后女性纳入本研究。MS根据联合定义进行定义。我们评估了MS的存在与血管结构指标（颈动脉内膜中层厚度（IMT）；动脉粥样硬化斑块）和功能指标（血流介导的血管舒张（FMD）；脉搏波速度（PWV））之间的关联。女性的平均年龄为56.4±6.7岁，平均绝经年龄为7.91±6.31岁。我们的人群中17.3%存在MS。PWV的平均值随MS特征的累积呈线性增加。与无MS的女性相比，有MS的女性IMT更高（0.78±0.12mm对0.74±0.11，p = 0.003）。多变量分析显示，MS的存在与颈总动脉IMT（b = 0.149，p = 0.001）、PWV（b = 0.114，p = 0.012）以及中心收缩压和舒张压（分别为b = 0.293，p < 0.001和b = 0.163，p < 0.001）独立相关。在这一样本的无症状、非糖尿病绝经后女性中，MS的存在在绝经后的第一个十年就与亚临床动脉粥样硬化相关。需要更多证据来支持这些关联的因果效应。
