高甘油三酯血症对代谢综合征患者动脉参数的影响。
Hypertriglyceridemia impact on arterial parameters in patients with metabolic syndrome.
机构信息
Faculty of Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius University, Santariskiu Str. 2, 08661, Vilnius, Lithuania.
Faculty of Mathematics and Informatics, Vilnius University, Vilnius, Lithuania.
出版信息
BMC Cardiovasc Disord. 2021 Aug 13;21(1):393. doi: 10.1186/s12872-021-02202-3.
BACKGROUND
The development of metabolic syndrome (MS) augments risk for atherosclerotic cardiovascular disease (CVD), but pathophysiological mechanisms of this relation are still under discussion. Overlapping CVD risk factors make it difficult to assess the importance of individual elements. This study aimed to analyze subclinical atherosclerosis based on arterial structure and function parameters in patients with MS and different triglycerides levels.
METHODS
Patients (aged 40-65 years) were divided into two groups: patients with MS and with or without hypertriglyceridemia (hTG). Noninvasive assessment of vascular parameters-aortic augmentation index adjusted for heart rate 75 bpm (AIxHR75), pulse wave velocity (PWV), and common carotid artery intima-media thickness (cIMT) were performed.
RESULTS
Carotid-femoral PWV (cfPWV) and carotid-radial PWV (crPWV) were significantly higher in patients with hTG. After adjusting for age, gender, waist circumference, fasting glucose, smoking status, cardiovascular family history and mean arterial pressure, crPWV (OR 1.150; CI 95% 1.04-1.28), cfPWV (OR 1.283; CI 95% 1.14-1.42) and cIMT (OR 1.13; CI 95% 1.02-1.25) were significantly associated with hTG (p < 0.05), while AIxHR75 did not show significant association.
CONCLUSION
Increased triglycerides are independently associated with a cfPWV, crPWV, and cIMT and may modify CVD risk in patients with MS.
背景
代谢综合征（MS）的发展增加了动脉粥样硬化性心血管疾病（CVD）的风险，但这种关系的病理生理机制仍在讨论中。重叠的 CVD 危险因素使得评估单个因素的重要性变得困难。本研究旨在分析基于 MS 患者和不同甘油三酯水平的动脉结构和功能参数的亚临床动脉粥样硬化。
方法
将患者（年龄 40-65 岁）分为两组：MS 患者和有或无高甘油三酯血症（hTG）的患者。对血管参数进行非侵入性评估-心率为 75 bpm 校正的主动脉增强指数（AIxHR75）、脉搏波速度（PWV）和颈总动脉内膜中层厚度（cIMT）。
结果
hTG 患者的颈动脉-股动脉 PWV（cfPWV）和颈动脉-桡动脉 PWV（crPWV）显著升高。在校正年龄、性别、腰围、空腹血糖、吸烟状况、心血管家族史和平均动脉压后，crPWV（OR 1.150；95%CI 1.04-1.28）、cfPWV（OR 1.283；95%CI 1.14-1.42）和 cIMT（OR 1.13；95%CI 1.02-1.25）与 hTG 显著相关（p<0.05），而 AIxHR75 与 hTG 无显著相关性。
结论
升高的甘油三酯与 cfPWV、crPWV 和 cIMT 独立相关，并可能改变 MS 患者的 CVD 风险。
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