Posner J, Burke C A
Psychopharmacology (Berl). 1985;87(4):468-72. doi: 10.1007/BF00432515.
Two double blind cross-over studies were performed using a submaximal effort tourniquet test (SETT) in healthy volunteers to investigate the role of endogenous opioids in placebo analgesia. In the first study IV naloxone significantly inhibited analgesia, miosis and sedation produced by the opioid dipipanone 10 mg in 12 subjects. In the second naloxone, which did not produce hyperalgesia, failed to inhibit significant placebo analgesia in 12 subjects. The results do not support the involvement of endogenous opioids in ischemic limb pain or placebo analgesia under these conditions.
在健康志愿者中进行了两项双盲交叉研究，采用次最大努力止血带试验（SETT）来研究内源性阿片类物质在安慰剂镇痛中的作用。在第一项研究中，静脉注射纳洛酮显著抑制了12名受试者中由10毫克阿片类药物二苯哌己酮产生的镇痛、瞳孔缩小和镇静作用。在第二项研究中，未产生痛觉过敏的纳洛酮未能抑制12名受试者中显著的安慰剂镇痛作用。这些结果不支持在这些条件下内源性阿片类物质参与缺血性肢体疼痛或安慰剂镇痛。
