Liu Rangdong, Su Yalun, Yang Jianbo, Wang Aiguo
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Phytochemistry. 2017 Oct;142:38-50. doi: 10.1016/j.phytochem.2017.06.011. Epub 2017 Jul 1.
Fourteen phloroglucinols, named hyperciumoxide A-N, and a known compound were isolated from air-dried aerial parts of Hypericum scabrum. The structures of these compounds were deduced on the basis of extensive 1D- and 2D-NMR experiments. Hepatoprotective properties against D-galactosamine-induced HL-7702 cell damage of isolated compounds were evaluated. Meanwhile, these compounds were also tested for antidepressant activity by inhibiting reuptake of tritiated serotonin ([H]-5-HT) and Noradrenalinet ([H]-NE) in rat brain synaptosomes.
从糙叶金丝桃的风干地上部分分离得到14种间苯三酚，命名为金丝桃氧化物A - N，以及一种已知化合物。这些化合物的结构通过广泛的一维和二维核磁共振实验推导得出。评估了分离出的化合物对D - 半乳糖胺诱导的HL - 7702细胞损伤的保肝性能。同时，还通过抑制大鼠脑突触体中氚化5 - 羟色胺（[H] - 5 - HT）和去甲肾上腺素（[H] - NE）的再摄取来测试这些化合物的抗抑郁活性。
