State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
Xinjiang Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang , Urumqi 830004, People's Republic of China.
J Nat Prod. 2016 Jun 24;79(6):1538-47. doi: 10.1021/acs.jnatprod.5b01063. Epub 2016 Jun 9.
Twenty polycyclic polyprenylated acylphloroglucinols (PPAPs), including the new compounds hyperscabrones A-I (1-9), were isolated from the air-dried aerial parts of Hypericum scabrum. These compounds comprise seven different structural types. All structures were determined by NMR spectroscopic methods and both experimental and calculated electronic circular dichroism (ECD) spectra. The evaluation of their neuroprotective effects on glutamate-induced toxicity in SK-N-SH cells showed that compounds 4-7 exhibited significant neuroprotection at 10 μM. Additionally, compounds 3, 4, 7, and 9 showed moderate hepatoprotective activities against paracetamol-induced HepG2 cell damage at 10 μM.
从干燥的贯叶连翘地上部分分离得到 20 个多环多聚烯基酰基间苯三酚（PPAPs），包括新化合物 hyperscabrones A-I（1-9）。这些化合物包含七种不同的结构类型。所有结构均通过 NMR 光谱方法以及实验和计算的电子圆二色性（ECD）光谱确定。评估它们对谷氨酸诱导的 SK-N-SH 细胞毒性的神经保护作用表明，化合物 4-7 在 10 μM 时表现出显著的神经保护作用。此外，化合物 3、4、7 和 9 在 10 μM 时对乙酰氨基酚诱导的 HepG2 细胞损伤表现出适度的肝保护活性。
