Macefield G, Nail B S
Respir Physiol. 1985 Nov;62(2):169-79. doi: 10.1016/0034-5687(85)90112-4.
Intratracheal inhalation of amyl nitrite, a non-specific smooth muscle relaxant, in the pentobarbitone/urethane anaesthetized rabbit caused reductions in tidal volume and both inspiratory and expiratory times, without a preceding apnoea, that were independent of the associated hypotension and of reflex influences from the carotid sinus region but dependent on supra-abdominal vagal integrity. In artificially ventilated, paralyzed rabbits amyl nitrite caused a pronounced sensitization of pulmonary stretch receptors (PSRs) during the inflation phase, typically with a reduction in the level of activity during the deflation phase. The time course of the change in the pattern of PSR activity paralleled that of the tachypnoeic response. The sensitization of a small sample of rapidly adapting 'irritant' receptors was of a significantly shorter duration. A unitary analysis of non-myelinated vagal afferents was not attempted. The sensitization of these vagal afferents cannot be attributed to the smooth muscle relaxant properties of amyl nitrite since other relaxants (sodium nitrite, sodium nitroprusside, phentolamine) did not possess this capacity, and such properties would be expected to diminish their activities.
在戊巴比妥/乌拉坦麻醉的兔子中，气管内吸入非特异性平滑肌松弛剂亚硝酸异戊酯，导致潮气量以及吸气和呼气时间减少，且无前驱呼吸暂停，这些变化独立于相关的低血压以及来自颈动脉窦区域的反射影响，但依赖于膈上迷走神经的完整性。在人工通气、麻痹的兔子中，亚硝酸异戊酯在充气阶段引起肺牵张感受器（PSR）明显敏感，通常在呼气阶段活动水平降低。PSR活动模式变化的时间进程与呼吸急促反应的时间进程平行。一小部分快速适应的“刺激”感受器的敏感化持续时间明显较短。未尝试对无髓鞘迷走神经传入纤维进行单一分析。这些迷走神经传入纤维的敏感化不能归因于亚硝酸异戊酯的平滑肌松弛特性，因为其他松弛剂（亚硝酸钠、硝普钠、酚妥拉明）不具备这种能力，而且预计这种特性会降低它们的活性。
